Benidipine reduces ischemia/reperfusion injury following testicular torsion/detorsion in rats

Authors

  • Monireh Khordadmehr Department of Pathobiology, Faculty of Veterinary Medicine, University of Tbriz, Tabriz, Iran
  • Sara Javanmardi Department of clinical sciences , faculty of veterinary medicine, university of Tabriz, Tabriz, Iran
Abstract:

Objective-This study aimed to determine the protective effects of benidipine on testicular injury after testis torsion/detorsion in ratsDesign-Experimental study Animals-Fifteen male Sprague-Dawly rats weighing 200-220g Procedure-Rats were randomly divided into 3 groups: sham (healthy group with sham operation, n=5), IRC group (control group in which I/R injury was performed by torsion the right testis 720 º clockwise for 2 hours and detorsion for 2 hours, n=5), and IRB group (IR + benidipine, I/R process was performed following orally benidipine administration + 4 mg/kg benidipine, n=5). Levels of glutathione peroxidase (GPx) and malondialdehyde (MDA) were determined in testicular tissues of rats. Testicular tissues were also examined histopathologically. Results-The levels of MDA (P<0.0001) was significantly increased augmented in the testis of IRC group rat. Testicular GPx levels were significantly reduced (p<0.0001) after I/R. Administration of benidipine before torsion prevented the increase in lipid peroxidation and alleviated GPx levels. Benidipine also impeded ischemia/reperfusion cellular damage and histological alternations in testicular tissue Conclusion and clinical relevance-These results show that therapy with benidipine before torsion may induce protective effects against ischemia/reperfusion injury

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Journal title

volume 12  issue 2

pages  21- 30

publication date 2017-12-01

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